• Kbiotech industrial systems are designed and manufactured for easy operation, accessible components and with safety in mind:
• Clean steam, sterile gas, and product contact lines are orbitally butt welded to the maximum extent possible.
• Our approach to equipment design is to engage in a discussion of detailed project requirements with our customers.
• We ensure that our proposal meets the technical process, time to market and commercial requirements for the completion of a successful project.
• The main objective of Kbiotech is to provide our clients with turn-key solutions for the engineering and technical management of their projects, so they can achieve the best targets.
• Kbiotech will assist you in procuring and delivering to the production plants all the necessary supplies, equipment, and instrumentation from lab scale to production, and final formulation and manufacturing of the products.

Expertise

• Process engineering (P&ID, functional analysis)
• Mechanical design (vessels and piping – 3D isometric drawings).
• Electrical and control system design, programming
• Piping manufacture and wiring
• Commissioning and after-sales service
• Qualification and Validation (cGMP, GAMP, CFR21 part 11)
• Design Qualification (DQ)
• Installation Qualification (IQ)
• Operational Qualification (OQ)
• Factory Acceptance Test (FAT)
• Site Acceptance Test (SAT)
• Performance Qualification (PQ)

Online Analyzers available to optimize process control

KG-Ferm KBiotech Gas analyzer for online monitoring of exhaust gases for the calculation of respiratory quotients and metabolic activity. Gases available: O2, CO2, CH4, H2, CO, and more available on request.

KB-Incyte-VBC realtime monitoring of viable cell biomass based on capacitance measurement for cell culture and fermentation process.

All online analyzers can be connected to our Bioflex Software for online data acquisition, feedback control and predictive data analysis for process optimization and risk-based actions, PAT compliance.

KBiotech CIP/SIP System for in situ steam sterilization and cleaning

The All-in-one solution from KBiotech is a unique device in a single compact and integrated system for the sterilization and cleaning of your bioreactor or fermenter.

BIOFLEX™ SOFTWARE

BIOFLEX™ Software intelligent interface, easily accessible for beginners and experienced users alike. Thanks to the intuitive user interface, Bioflex is simple to operate, limiting operator errors and reducing training needs.

BIO-FLEX™ is a bioprocess software designed for R&D, process development, optimization and scale up to industrialization.

Bioflex is high flexibility for a batch, fed-batch or a continuous culture with Advanced control strategies (pH STAT, DO STAT, Turbidostat, exponential, complex calculations), perfusion programs, offline data and profiles management, data batch records, data export to Excel and more.

This open-source Software allows to integrate, at any time, conventional and sophisticated online sensors such as Biomass Monitor, Gas analyzers, pCO2 probe, Glucose and Multi-assay analyzers and actuators (pumps, MFC or Rotameters, valves, etc.).

Bioflex software supports the latest Windows platforms and can be installed on a laptop, PC workstation, tablet or smartphone, enabling you to monitor and control your bioreactor at any time: in the laboratory, in the office or even at home. Bioflex Software is able to manage and control up 12-24-36 Compact bioreactors online, accelerating the development of your bioprocesses. Bioflex CFR21 part 11 compliance version for GMP applications is available.

BIOFLEX FEATURES

• Management of algorithms and complex control (cascade modes, sequences, profiles etc.)
• Management of culture and manufacturing files
• Management of BATCH recipes.
• Programming of control set points according to a profile set by the operator or a previous batch file
• “Calculation” module allowing the calculation of derived variables
• The software can manage a library of culture files containing standard conditions of culture for each microorganism.
• Every time a cycle is launched, the operator can select the file of their choice, by adjusting the parameters.
• At the end of fermentation, a summary manufacturing file is created and archived.
• High and low alarm options with safety measures